Focus
My scientific work sits at the intersection of biochemistry and computation. I've spent years studying how enzymes behave when attached to solid supports — a deceptively hard problem that determines whether a biocatalytic process is economically viable or not. That passion led me to start inseit.
At inseit, we're building an AI-powered platform that predicts and optimises how enzymes are immobilised on support materials for industrial applications. We work with companies in pharma, food, and environmental chemistry who need faster, more reliable enzyme development pipelines. Backed by University of Bern, Venture Kick, and BRIDGE, among others.
Immobilization of Thrombin on Agarose-Based Supports for Affinity Tag Removal
Almada, J.C.; Marco-Martin, M.; Roura Padrosa, D.; Velasco-Lozano, S.. Biomacromolecules. DOI ↗
Crystallization-Assisted Asymmetric Synthesis of Enantiopure Amines Using Membrane-Immobilized Transaminase
Meersseman Arango, H.; Bachus, N.; Nguyen, X.D.L.; Bredun, B.; Luis, P.; Leyssens, T.; Roura Padrosa, D.; Paradisi, F.; Debecker, D.P.. Chem & Bio Engineering. DOI ↗
Biocatalysis in packed-bed reactors: immobilization as an enabling technology
Fernández Regueiro, C.L.; Roura Padrosa, D.; Paradisi, F.. Comptes Rendus. Chimie. DOI ↗
Biocatalytic Reduction of Heterocyclic Imines in Continuous Flow with Immobilized Enzymes
Benítez-Mateos, A.I.; Lim, D.; Roura Padrosa, D.; Marchini, V.; Wu, H.; Buono, F.; Paradisi, F.. ACS Sustainable Chemistry & Engineering. DOI ↗
A novel ene-reductase from Halomonas elongata for flow biocatalytic synthesis
Pillet, L.; Fernández Regueiro, C.L.; Busch, M.R.; Roura Padrosa, D.; Paradisi, F.. RSC Advances. DOI ↗
Microtiter Plate Immobilization Screening for Prototyping Heterogeneous Enzyme Cascades
López, I.L.; Sánchez-Costa, M.; Orrego, A.H.; Zeballos, N.; Roura Padrosa, D.; López-Gallego, F.. Angewandte Chemie. DOI ↗
Solvent Switching in Continuous Multistep Chemoenzymatic Synthesis
Díaz-Kruik, P.; Roura Padrosa, D.; Hegarty, E.; Lehmann, H.; Snajdrova, R.; Paradisi, F.. Organic Process Research & Development. DOI ↗
Biocatalyst Immobilization and Process Intensification: Production of (S)-Piperazine-2-carboxylic Acid
Roura Padrosa, D.; Wetzl, D.; Hildbrand, S.; Tosatti, P.; Sedelmeier, J.; Puentener, K.; Iding, H.; Paradisi, F.. Organic Process Research & Development. DOI ↗
Flow Biocatalysis for Chiral Molecules Synthesis
Roura Padrosa, D.; Benitez-Mateos, Ana I.; Paradisi, F.. Comprehensive Chirality. DOI ↗
Membrane-immobilized transaminases for the synthesis of enantiopure amines
Meersseman Arango, H.; Nguyen, X.D.L.; Luis, P.; Leyssens, T.; Roura Padrosa, D.; Paradisi, F.; Debecker, D.P.. RSC Sustainability. DOI ↗
Optimising Electrical Interfacing between the Trimeric Copper Nitrite Reductase and Carbon Nanotubes
Contaldo, U.; Padrosa, D.R.; Jamet, Hélèn.; Albrecht, M.; Paradisi, F.; Le Goff, A.. Chemistry – A European Journal. DOI ↗
Bioinformatic Analysis of Immobilized Enzymes: Towards a Better Understanding
Roura Padrosa, D.; Paradisi, F.. ChemBioChem. DOI ↗
Sustainable synthesis of L-phenylalanine derivatives in continuous flow by
Roura Padrosa, D.; Lehmann, H.; Snajdrova, R.; Paradisi, F.. Frontiers in Catalysis. DOI ↗
Back to the future: taking enzymes to the next level of sustainability
Padrosa, D.R.; Benítez-Mateos, A.I.; Paradisi, F.. The Biochemist. DOI ↗
Multistep enzyme cascades as a route towards green and sustainable pharmaceutical syntheses
Benítez-Mateos, A.I.; Roura Padrosa, D.; Paradisi, F.. Nature Chemistry. DOI ↗
How can Enzymes Help us With Manufacturing?
Roura Padrosa, D.; Paradisi, F.. Frontiers for Young Minds. DOI ↗
A novel thymidine phosphorylase to synthesize (halogenated) anticancer and antiviral nucleoside drugs
Benítez-Mateos, A.I.; Klein, C.; Roura Padrosa, D.; Paradisi, F.. Catalysis Science & Technology. DOI ↗
Combined chemoenzymatic strategy for sustainable continuous synthesis of hordenine
Gianolio, S.; Roura Padrosa, D.; Paradisi, F.. Green Chemistry. DOI ↗
Fusion of Glutamate Dehydrogenase and Formate Dehydrogenase Yields a Bifunctional Efficient Biocatalyst for the Continuous Removal of Ammonia
Marchini, V.; Benítez-Mateos, A.I.; Roura Padrosa, D.; Paradisi, F.. Frontiers in Catalysis. DOI ↗
Efficient Amino Donor Recycling in Amination Reactions
Roura Padrosa, D.; Nisar, Z.; Paradisi, F.. Catalysts. DOI ↗
CapiPy: python-based GUI-application to assist in protein immobilization
Roura Padrosa, D.; Marchini, V.; Paradisi, F.. Bioinformatics. DOI ↗
Flow biocatalysis 101: design, development and applications
Benítez-Mateos, A.I.; Contente, M.L.; Roura Padrosa, D.; Paradisi, F.. Reaction Chemistry & Engineering. DOI ↗
Minimalistic peptidic scaffolds harbouring an artificial carbene-containing amino acid
Lenzen, K.; Planchestainer, M.; Feller, I.; Roura Padrosa, D.; Paradisi, F.; Albrecht, M.. Chemical Communications. DOI ↗
Multi-gram preparation of cinnamoyl tryptamines as skin whitening agents
Roura Padrosa, D.; Contente, M.L.. Tetrahedron Letters. DOI ↗
A strategic Ser/Cys exchange in the catalytic triad unlocks acyltransferase-mediated synthesis
Contente, M.L.; Roura Padrosa, D.; Molinari, F.; Paradisi, F.. Nature Catalysis. DOI ↗
Uncommon overoxidative catalytic activity in a new halo-tolerant alcohol dehydrogenase
Contente, M.L.; Fiore, N.; Cannazza, P.; Roura Padrosa, D.; Molinari, F.; Gourlay, L.; Paradisi, F.. ChemCatChem. DOI ↗
CapiPy: Python Based GUI-Application to Assist in Protein Immobilization
Roura Padrosa, D.; Marchini, V.; Paradisi, F.. Bioinformatics. DOI ↗
Cell-free biocatalytic syntheses of L-pipecolic acid
Roura Padrosa, D.; Benítez-Mateos, A.I.; Calvey, L.; Paradisi, F.. Green Chemistry. DOI ↗
Enhancing PLP-Binding Capacity of Class-III ω-Transaminase
Roura Padrosa, D.; Alaux, R.; Smith, P.; Dreveny, I.; López-Gallego, F.; Paradisi, F.. Frontiers in Bioengineering and Biotechnology. DOI ↗
Overcoming Water Insolubility in Flow: Enantioselective Hydrolysis of Naproxen Ester
Roura Padrosa, D.; De Vitis, V.; Contente, M.L.; Molinari, F.; Paradisi, F.. Catalysts. DOI ↗
Construction of Highly Stable Cytotoxic Nuclear-Directed Ribonucleases
Roura Padrosa, D.; Castro, J.; Romero-Casañas, A.; Ribó, M.; Vilanova, M.; Benito, A.. Molecules. DOI ↗
Genetically Fused T4L Acts as a Shield in Covalent Enzyme Immobilisation Enhancing the Rescued Activity
Planchestainer, M.; Roura Padrosa, D.; Contente, M.; Paradisi, F.. Catalysts. DOI ↗