David
Roura Padrosa
CEO & Co-founder
inseit.ch · Bern, Switzerland
Building an AI-powered enzyme immobilisation platform for industrial biocatalysis. Backed by University of Bern, Venture Kick, and BRIDGE.
BRIDGE PoC Fellow
University of Bern · Bern, Switzerland
Post-doctoral researcher
University of Bern and Hoffman-La Roche · Bern, Switzerland
Post-doctoral researcher
University of Bern · Bern, Switzerland
PhD in Chemical Biology
University of Nottingham · United Kingdon
MSc in Molecular Biology and Biomedicine
University of Girona · Spain
BSc in Biology
University of Girona · Spain
MSCA Doctoral Network RADICALLY – PhD Co-supervision PhD
inSEIT AG / University of Bern
Co-supervising PhD researchers in the EU Horizon Europe MSCA Doctoral Network RADICALLY consortium (lead: Durham University).
From university to a deep tech spin-off: the inSEIT story PhD
University of Bern
Keynote lecture for the PhD Coalition Leadership Lecture Series on transitioning from academia to founding a deep-tech startup.
Protein Bioinformatics MSc
University of Bern
Almada, J.C.; Marco-Martin, M.; Roura Padrosa, D.; Velasco-Lozano, S. “Immobilization of Thrombin on Agarose-Based Supports for Affinity Tag Removal.” Biomacromolecules, 2025. DOI ↗
Meersseman Arango, H.; Bachus, N.; Nguyen, X.D.L.; Bredun, B.; Luis, P.; Leyssens, T.; Roura Padrosa, D.; Paradisi, F.; Debecker, D.P. “Crystallization-Assisted Asymmetric Synthesis of Enantiopure Amines Using Membrane-Immobilized Transaminase.” Chem & Bio Engineering, 2025. DOI ↗
Fernández Regueiro, C.L.; Roura Padrosa, D.; Paradisi, F. “Biocatalysis in packed-bed reactors: immobilization as an enabling technology.” Comptes Rendus. Chimie, 2025. DOI ↗
Benítez-Mateos, A.I.; Lim, D.; Roura Padrosa, D.; Marchini, V.; Wu, H.; Buono, F.; Paradisi, F. “Biocatalytic Reduction of Heterocyclic Imines in Continuous Flow with Immobilized Enzymes.” ACS Sustainable Chemistry & Engineering, 2025. DOI ↗
Pillet, L.; Fernández Regueiro, C.L.; Busch, M.R.; Roura Padrosa, D.; Paradisi, F. “A novel ene-reductase from Halomonas elongata for flow biocatalytic synthesis.” RSC Advances, 2025. DOI ↗
López, I.L.; Sánchez-Costa, M.; Orrego, A.H.; Zeballos, N.; Roura Padrosa, D.; López-Gallego, F. “Microtiter Plate Immobilization Screening for Prototyping Heterogeneous Enzyme Cascades.” Angewandte Chemie, 2024. DOI ↗
Díaz-Kruik, P.; Roura Padrosa, D.; Hegarty, E.; Lehmann, H.; Snajdrova, R.; Paradisi, F. “Solvent Switching in Continuous Multistep Chemoenzymatic Synthesis.” Organic Process Research & Development, 2024. DOI ↗
Roura Padrosa, D.; Wetzl, D.; Hildbrand, S.; Tosatti, P.; Sedelmeier, J.; Puentener, K.; Iding, H.; Paradisi, F. “Biocatalyst Immobilization and Process Intensification: Production of (S)-Piperazine-2-carboxylic Acid.” Organic Process Research & Development, 2024. DOI ↗
Roura Padrosa, D.; Benitez-Mateos, Ana I.; Paradisi, F. “Flow Biocatalysis for Chiral Molecules Synthesis.” Comprehensive Chirality, 2024. DOI ↗
Meersseman Arango, H.; Nguyen, X.D.L.; Luis, P.; Leyssens, T.; Roura Padrosa, D.; Paradisi, F.; Debecker, D.P. “Membrane-immobilized transaminases for the synthesis of enantiopure amines.” RSC Sustainability, 2024. DOI ↗
Contaldo, U.; Padrosa, D.R.; Jamet, Hélèn.; Albrecht, M.; Paradisi, F.; Le Goff, A. “Optimising Electrical Interfacing between the Trimeric Copper Nitrite Reductase and Carbon Nanotubes.” Chemistry – A European Journal, 2023. DOI ↗
Roura Padrosa, D.; Paradisi, F. “Bioinformatic Analysis of Immobilized Enzymes: Towards a Better Understanding.” ChemBioChem, 2023. DOI ↗
Roura Padrosa, D.; Lehmann, H.; Snajdrova, R.; Paradisi, F. “Sustainable synthesis of L-phenylalanine derivatives in continuous flow by.” Frontiers in Catalysis, 2023. DOI ↗
Padrosa, D.R.; Benítez-Mateos, A.I.; Paradisi, F. “Back to the future: taking enzymes to the next level of sustainability.” The Biochemist, 2022. DOI ↗
Benítez-Mateos, A.I.; Roura Padrosa, D.; Paradisi, F. “Multistep enzyme cascades as a route towards green and sustainable pharmaceutical syntheses.” Nature Chemistry, 2022. DOI ↗
Roura Padrosa, D.; Paradisi, F. “How can Enzymes Help us With Manufacturing?.” Frontiers for Young Minds, 2022. DOI ↗
Benítez-Mateos, A.I.; Klein, C.; Roura Padrosa, D.; Paradisi, F. “A novel thymidine phosphorylase to synthesize (halogenated) anticancer and antiviral nucleoside drugs.” Catalysis Science & Technology, 2022. DOI ↗
Gianolio, S.; Roura Padrosa, D.; Paradisi, F. “Combined chemoenzymatic strategy for sustainable continuous synthesis of hordenine.” Green Chemistry, 2022. DOI ↗
Marchini, V.; Benítez-Mateos, A.I.; Roura Padrosa, D.; Paradisi, F. “Fusion of Glutamate Dehydrogenase and Formate Dehydrogenase Yields a Bifunctional Efficient Biocatalyst for the Continuous Removal of Ammonia.” Frontiers in Catalysis, 2021. DOI ↗
Roura Padrosa, D.; Nisar, Z.; Paradisi, F. “Efficient Amino Donor Recycling in Amination Reactions.” Catalysts, 2021. DOI ↗
Roura Padrosa, D.; Marchini, V.; Paradisi, F. “CapiPy: python-based GUI-application to assist in protein immobilization.” Bioinformatics, 2021. DOI ↗
Benítez-Mateos, A.I.; Contente, M.L.; Roura Padrosa, D.; Paradisi, F. “Flow biocatalysis 101: design, development and applications.” Reaction Chemistry & Engineering, 2021. DOI ↗
Lenzen, K.; Planchestainer, M.; Feller, I.; Roura Padrosa, D.; Paradisi, F.; Albrecht, M. “Minimalistic peptidic scaffolds harbouring an artificial carbene-containing amino acid.” Chemical Communications, 2021. DOI ↗
Roura Padrosa, D.; Contente, M.L. “Multi-gram preparation of cinnamoyl tryptamines as skin whitening agents.” Tetrahedron Letters, 2021. DOI ↗
Contente, M.L.; Roura Padrosa, D.; Molinari, F.; Paradisi, F. “A strategic Ser/Cys exchange in the catalytic triad unlocks acyltransferase-mediated synthesis.” Nature Catalysis, 2020. DOI ↗
Contente, M.L.; Fiore, N.; Cannazza, P.; Roura Padrosa, D.; Molinari, F.; Gourlay, L.; Paradisi, F. “Uncommon overoxidative catalytic activity in a new halo-tolerant alcohol dehydrogenase.” ChemCatChem, 2020. DOI ↗
Roura Padrosa, D.; Marchini, V.; Paradisi, F. “CapiPy: Python Based GUI-Application to Assist in Protein Immobilization.” Bioinformatics, 2020. DOI ↗
Roura Padrosa, D.; Benítez-Mateos, A.I.; Calvey, L.; Paradisi, F. “Cell-free biocatalytic syntheses of L-pipecolic acid.” Green Chemistry, 2020. DOI ↗
Roura Padrosa, D.; Alaux, R.; Smith, P.; Dreveny, I.; López-Gallego, F.; Paradisi, F. “Enhancing PLP-Binding Capacity of Class-III ω-Transaminase.” Frontiers in Bioengineering and Biotechnology, 2019. DOI ↗
Roura Padrosa, D.; De Vitis, V.; Contente, M.L.; Molinari, F.; Paradisi, F. “Overcoming Water Insolubility in Flow: Enantioselective Hydrolysis of Naproxen Ester.” Catalysts, 2019. DOI ↗
Roura Padrosa, D.; Castro, J.; Romero-Casañas, A.; Ribó, M.; Vilanova, M.; Benito, A. “Construction of Highly Stable Cytotoxic Nuclear-Directed Ribonucleases.” Molecules, 2018. DOI ↗
Planchestainer, M.; Roura Padrosa, D.; Contente, M.; Paradisi, F. “Genetically Fused T4L Acts as a Shield in Covalent Enzyme Immobilisation Enhancing the Rescued Activity.” Catalysts, 2018. DOI ↗
From university to a deep tech spin-off: the inSEIT story
PhD Coalition Leadership Lecture Series · University of Bern, Switzerland · 2026
Startup pitch – Deep Tech Atelier 2026
Deep Tech Atelier · Riga, Latvia · 2026
Analytica 2026
Analytica 2026 · Munich, Germany · 2026
GBD 2026
GBD 2026 · 2026
Pizza & Pitches
Pizza & Pitches · 2026
How can we improve enzyme immobilization with in silico tools?
Dept. Chemistry, Biochemistry & Pharmaceutical Sciences House Seminar · University of Bern, Switzerland · 2025
Swiss International Chemical Sciences (SICS 2025)
SICS 2025 · Switzerland · 2025
BiotecSpain 2025
BiotecSpain 2025 · 2025
Swiss Biotech Day 2025
Swiss Biotech Day · Basel, Switzerland · 2025
Start Summit 2025
Start Summit · St. Gallen, Switzerland · 2025
Nucleate kick-off
Nucleate · 2025
Immobilize to go further – inSEIT AG
iCANX Davos Summit · Davos, Switzerland · 2024
Data-driven tools for compatible biocatalysis
Swiss Biotech Day · Basel, Switzerland · 2024
Founders Forum 2024
Founders Forum · 2024
Immobilize to go further – bioinformatics' role in advancing enzyme immobilization
CLASSY Industry Workshop · 2023
How enzyme immobilization can help in process intensification
ISPROCHEM · Milan, Italy · 2023
Deep Tech Atelier 2026 Prize
Deep Tech Atelier / Goal Events
Prize awarded at the Deep Tech Atelier startup competition in Riga, Latvia.
W.A. de Vigier Award – Finalist
W.A. de Vigier Foundation
Finalist for one of Switzerland's most prestigious entrepreneurship awards (CHF 100K per winner).
W.A. de Vigier Award – Finalist
W.A. de Vigier Foundation
Finalist for one of Switzerland's most prestigious entrepreneurship awards.
Venture Leaders Biotech
VentureLab Switzerland
Selected among 10 Swiss deep-tech startups for a week-long investor roadshow in Boston, MA.
Nucleate Switzerland Activator – Scientific Excellence & Novel Idea
Nucleate Switzerland
Two prizes: Scientific Excellence (USD 1,000) and Novel Idea (CHF 6,000).
YPSOMED Award – Finalist
YPSOMED
MSCA Doctoral Network RADICALLY
European Commission – Horizon Europe Participant
BRIDGE Proof of Concept
BRIDGE (Innosuisse) Main applicant
197000
Venture Kick
Venture Kick Main applicant
50000
JM & The Bakery Open Innovation
Johnson Matthey & The Bakery Main applicant
3000